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  • CNG - Programmes
    FGENTCARD GABRIEL GENESKIN IMAGEN MOLPAGE MOLTOOLS PROCARDIS STAR Programmes Européens EU PCRD5 EID DNA tracing EPIGENOME EUMORPHIA EURAGEDIC EURNETGEN EUROAS GENOMIC BANK INFRAQTL MADO Autres programmes franco japonaise franco croate PHENOGENE EPIGENOME Pilot Study for a Human Epigenome Project Coordinator Contact Person William Murray CAIRNS Mr Organisation GENOME RESEARCH LTD THE WELLCOME TRUST SANGER INSTITUTE The Wellcome Trust Genome Campus Hinxton CB10 1SA SAFFRON WALDEN UNITED KINGDOM Web site http www epigenome org Project description Objectives To demonstrate the feasibility of a full scale Epigenome Project in the future To compare the methylation pattern for a defined set of 150 genes encompassing two loci per gene of the Major Histocompatibility Complex for 40 selected tissues A very high throughput epigenotyping facility is being developed for the analysis of large numbers of samples and establish haplotypes for a medium size set Initial studies are performed on lymphocyte samples from affected families Only loci of variable methylation and generic influences of haplotype on epigenotype will therefore be discovered In the second phase keratinocyte biopsies will be obtained from strictly selected set of psoriasis patients and a number of unaffected controls Loci that have been shown to be subject to variable methylation will

    Original URL path: http://www.cng.fr/fr/projects/fp5_epigenome.html (2016-01-29)
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  • CNG - Programmes
    Programmes Européens EU PCRD5 EID DNA tracing EPIGENOME EUMORPHIA EURAGEDIC EURNETGEN EUROAS GENOMIC BANK INFRAQTL MADO Autres programmes franco japonaise franco croate PHENOGENE EUMORPHIA Understanding human molecular physiology and pathology through integrated functional genomics in the mouse model Coordinator Contact Person Nigel WATTS Mr Organisation MEDICAL RESEARCH COUNCIL MAMMALIAN GENETICS UNIT Harwell OX11 0RD DIDCOT HARWELL CHILTON UNITED KINGDOM Project description The consortium will undertake an integrated approach to the development and characterisation of new mouse models of human diseases and in so doing contribute in a profound way to understanding human physiology and pathology The three main elements Phenotyping Mutagenesis and Informatics in the workplan run in parallel Each workpackage contains the following common themes Working groups to evaluate and integrate proposed assays to propose define standard protocols and consider animal welfare issues to disseminate the standard protocols to use the standard protocols to acquire baseline longitudinal data on a variety of inbred strains and relevant existing models to develop innovative phenotyping approaches for subsequent implementation Participants THE NETHERLANDS CANCER INSTITUTE ANTONI VAN LEEUWENHOEK HOSPITAL NETHERLANDS GSF RESEARCH CENTER FOR ENVIRONMENT AND HEALTH GERMANY UNIVERSITY OF LAUSANE SWITZERLAND GENOME RESEARCH LTD UNITED KINGDOM KAROLINSKA INSTITUTE SWEDEN UNIVERSITY OF MANCHESTER

    Original URL path: http://www.cng.fr/fr/projects/fp5_eumorphia.html (2016-01-29)
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  • CNG - Programmes
    PCRD6 EURATOOLS EUROHEAR FGENTCARD GABRIEL GENESKIN IMAGEN MOLPAGE MOLTOOLS PROCARDIS STAR Programmes Européens EU PCRD5 EID DNA tracing EPIGENOME EUMORPHIA EURAGEDIC EURNETGEN EUROAS GENOMIC BANK INFRAQTL MADO Autres programmes franco japonaise franco croate PHENOGENE EURAGEDIC EUropean Rational Approach for the GEnetics of DIabetic Complications Coordinator Contact Person Christian BRECHOT Mr Organisation INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FACULTE DE MEDECINE PITIE SALPETRIERE U525 Boulevard de l Hôpital 91 75634 PARIS FRANCE Project description To develop an existing interdisciplinary research collaboration with the major objective of combining clinical and genetic approaches to identify the biological pathways involved in the pathogenesis of diabetic complications in human and rodents New genomic approaches will be applied to a unique set of clinical resources to create a study with high power to identify genetic variants This relies on the possibility for extensive analysis of single nucleotide polymorphisms SNPs and other variants of many candidate genes that can be identified from the human genome sequence and the availability in our laboratories of reliable high throughput technologies for large scale characterization of these genetic variants Part 1 Phenotypic characterization of individuals Part 2 Identification of genes and pathways implicated in the diabetic complications

    Original URL path: http://www.cng.fr/fr/projects/fp5_euragedic.html (2016-01-29)
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  • CNG - Programmes
    EURATRANS EUROTALENTS EVA GEN2PHEN GEUVADIS LUPA READNA SYBARIS PROGRAMMES ARCHIVE Programmes Européens EU PCRD6 EURATOOLS EUROHEAR FGENTCARD GABRIEL GENESKIN IMAGEN MOLPAGE MOLTOOLS PROCARDIS STAR Programmes Européens EU PCRD5 EID DNA tracing EPIGENOME EUMORPHIA EURAGEDIC EURNETGEN EUROAS GENOMIC BANK INFRAQTL MADO Autres programmes franco japonaise franco croate PHENOGENE EURNETGEN European network to develop genetic markers for essential hypertension Coordinator Contact Person Susan FERGUSON Mrs Tel 44 14 13304992 Fax 44 14 13302747 Email Contact Organisation UNIVERSITY OF GLASGOW DEPARTMENT OF MEDICINE AND THERAPEUTICS University Avenue G12 8QQ Glasgow UNITED KINGDOM Project description To develop and evaluate a panel of novel SNPs within 100 candidate genes characterised by a putative pathophysiological link to essential hypertension and or its complication These genetic markers will undergo initial evaluation including the construction of haplotypes and testing for their functional significance on the existing DNA banks DZ twins and parents and nuclear families recruited by EPOGH European Project On Genes in Hypertension study At the same time TDT family trios 600 are collected in Glasgow Paris and Milan A special emphasis is on uniform high fidelity phenotyping which is made possible by common standard operating procedures stringent quality control system and common protocols for data analysis

    Original URL path: http://www.cng.fr/fr/projects/fp5_eurnetgen.html (2016-01-29)
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  • CNG - Programmes
    FGENTCARD GABRIEL GENESKIN IMAGEN MOLPAGE MOLTOOLS PROCARDIS STAR Programmes Européens EU PCRD5 EID DNA tracing EPIGENOME EUMORPHIA EURAGEDIC EURNETGEN EUROAS GENOMIC BANK INFRAQTL MADO Autres programmes franco japonaise franco croate PHENOGENE EUROAS GENOMIC BANK EUROAS European genomic bank and clinical genetic and immunogenetic database of Ankylosing Spondylitis and the other Spondyarthropathies Coordinator Contact Person Rose Marie VAN LERBERGHE Organisation ASSISTANCE PUBLIQUE HOPITAUX DE PARIS SERVICE DE RHUMATOLOGIE A Rue du Fbg St Jacques 27 Hopital Cochin 75674 PARIS FRANCE Project description Objectives To optimise and reinforce existing infrastructure of 6 partner laboratories and 9 clinical centres doing a task force To harmonise techniques already used DNA cell and sera extraction cell line establishment and to develop new techniques and standards To ensure quality control of HLA molecular typing procedures B27 subtyping distribution of reference DNA To provide a repository of Ankylosing Spondylitis AS and other Spondyarthropathies SPA DNA cells and sera thanks to up to 4000 already identified affected families with accurate clinical status affected unaffected disease severity allowing to determine susceptibility and severity factors of AS and SPA To coordinate fine gene mapping studies to identify new susceptibility MHC and non MHC genes To supply a centralised database with

    Original URL path: http://www.cng.fr/fr/projects/fp5_euroas.html (2016-01-29)
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  • CNG - Programmes
    GEUVADIS LUPA READNA SYBARIS PROGRAMMES ARCHIVE Programmes Européens EU PCRD6 EURATOOLS EUROHEAR FGENTCARD GABRIEL GENESKIN IMAGEN MOLPAGE MOLTOOLS PROCARDIS STAR Programmes Européens EU PCRD5 EID DNA tracing EPIGENOME EUMORPHIA EURAGEDIC EURNETGEN EUROAS GENOMIC BANK INFRAQTL MADO Autres programmes franco japonaise franco croate PHENOGENE INFRAQTL Rodent models for oligogenic human diseases infrastructure facilitating the progression from genetics to the gene containing the putative aetiological variant to the functional validation of genes pathways Coordinator Organisation MEDICAL RESEARCH COUNCIL MAMMALIAN GENETICS UNIT Harwell OX11 0RD DIDCOT HARWELL CHILTON UNITED KINGDOM Project description Genetic studies in rat and mouse models of human disorders have highlighted the complementary inputs provided by the two species in the genetic dissection of complex traits In order to take advantage of the access to novel gene functions promised by mouse and rat QTL studies an innovative infrastructure of both techniques and materials that provide strategic support for QTL research in Europe is prepared One of the major objectives is to co ordinate efforts and expertise between mouse and rat geneticists and to develop new infrastructures for QTL mapping high throughput genotype analysis and expression profiling systems applied to disease gene identification in rodents This project will lead to the

    Original URL path: http://www.cng.fr/fr/projects/fp5_infraqtl.html (2016-01-29)
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  • CNG - Programmes
    donors registries socio economic evaluation of molecular techniques and recruitment strategies Coordinator Contact Person Christian BRECHOT Mr Organisation INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE U 558 EPIDMIOLOGIE ET ANALYSES EN SANT PUBLIQUE RISQUES MALADIES CHRONIQUES ET HANDICAPS AllTes Jules Guesde 37 FacultT de MTdTcine Purpan 37073 Toulouse FRANCE Project description Although 6 million potential donors are registered worldwide finding a donor compatible for allogenic stem cell graft is hard because of HLA polymorphism MADO aims at evaluating optimisation of Registries in Europe by increasing the proportion of donors presenting rare HLA combinations to reduce inequality of patients in a cost effective way The main concept is an evolving filter to screen potential donors at low cost before full HLA typing for the likely presence of frequent types The overall expected achievement is a number of well documented possible scenarios to help decision for organisation of coherent strategies of Registry management 1st axis Test and evaluation of a possible filter that would allow to screen potential donors at low cost before full HLA typing for the likely presence of frequent or rare combinations using new markers and new technological approaches that would be adaptable to the actual

    Original URL path: http://www.cng.fr/fr/projects/fp5_mado.html (2016-01-29)
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  • CNG - Programmes
    identification de tous les gènes présents dans le génome Pour chaque individu de nombreuses différences existent entre la séquence provenant de son propre ADN et la séquence de référence en moyenne d une base toutes les 1000 bases mais l origine ethnique et la région du génome étudiée modifient la fréquence des différences Le programme de coopération franco japonaise vise à établir une carte des variantes génétiques de troisième génération et à vérifier leur implication dans les différences inter individuelles dans la prédisposition aux maladies ou à certains traits phénotypiques La découverte de variantes génétiques et leur association avec les maladies constitutent au plan international les programmes majeurs de recherche post génomique Objectifs Répertorier les variantes génétiques de 15 000 gènes dans les populations japonaise européenne africaine Méthode Les variantes génétiques sont mises en évidence par comparaison des séquences obtenues par séquençage direct des fragments d ADN amplifiés chez 32 individus pour chaque population Les amorces d oligonucléotides synthétisées pour le criblage couvrent les exons une partie des introns et les promoteurs des 15 000 gènes étudiés Développer des technologies de génotypage SNP Des plates formes de génotypage à haut débit sont développées par les deux centres avec l objectif d augmenter le débit actuel et de diminuer le coût de production Le CNG a mis en place une plate forme de génotypage par spectrométrie de masse en MALDI TOF Le CNG et le CGHT étudient d autres approches technologiques avec des partenaires extérieurs Etudier les associations entre les variantes génétiques et les maladies Le CNG et CGHT collaborent avec plusieurs groupes pour l établissement de grandes cohortes de patients atteints de pathologies communes telles que l asthme les complications du diabète et l infarctus du myocarde L analyse de l association de variantes génétiques d un gène à une

    Original URL path: http://www.cng.fr/fr/projects/other_fr_jap.html (2016-01-29)
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