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  • CNG - PROGRAMMES
    Programme Franco croatian coop PHENOGENE PROCARDIS A genome wide mapping and functional genomics approach to elucidating precocious coronary artery disease Coordinator Contact Person WATKINS Hugh Professor Tel 44 1865220257 Fax 44 1865768844 Email Contact Organisation THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD CLINCAL TRIALS SERVICE UNIT AND THE DEPARTMENT OF PUBLIC HEALTH AND PRIMARY CARE DEPARTMENT OF CARDIOVASCULAR MEDICINE University Offices Wellington Square UNITED KINGDOM Project description Procardis is a European Commission Framework 6 FP6 funded project which exploits advances in complex trait genetics and functional genomics to discover novel susceptibility genes for coronary artery disease CAD PROCARDIS is incorporating a definitive genome wide association analysis and measurement of novel intermediate phenotypes to yield biomarkers for CAD risk and quantitative traits for genetic analysis Cardiovascular mortality and morbidity in Europe which represents 1 3 to 1 2 of overall mortality rates hardly needs to be underlined Two well recognised general features characterise the cardiovascular mortality figures within Europe of which CAD accounts for between 1 3 and 2 3 a great inter country variability with decreasing East West and North South gradients and a falling prevalence in the Western and Southern countries contrasting the stable increasing rates in many Eastern countries The need for targeted studies with the aim of exploring the specific interaction between genetic and environmental risk factors is recognised as a priority The specific aims of the Procardis project are identify novel proteins and pathways implicated in atherosclerosis and arterial thrombosis define new targets for prevention and treatment devise diagnostic tools The Procardis project is funded with 10 million Euros through the 6th Framework Program of the European Union LSH 2005 2 1 1 1 The project is aimed to integrate the efforts of key European basic and clinical scientists into one cohesive effort

    Original URL path: http://www.cng.fr/en/projects/fp6_procardis.html (2016-01-29)
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  • CNG - PROGRAMMES
    description Inherited differences in DNA sequence contribute to phenotypic variation influencing an individual s risk of disease and response to the environment A central goal of genetics is to pinpoint the DNA variants that contribute most significantly to variation in each trait The rat is an important model organism for systems biology provides the most relevant models of common multifactorial human disease and it is by far the leading model species in pharmacology and toxicology It has been the major model for physiological investigation providing a body of data on patho physiology including detailed mechanistic biochemical and metabolic characterisation that cannot be replaced by other models Decades of exquisite phenotyping and detailed analysis of crosses of inbred rats have resulted in initial localization of hundreds of loci involved in complex disease and quantitative phenotypes but with very few eventual gene identifications to date A clear understanding of the origin and structure of genetic variation in the rat will provide a key missing piece of this puzzle To fully realize the power of the recent rat genome sequence we propose to initiate the complete genetic dissection of the ancestral segments making up the most commonly used inbred lines The proposed SNP

    Original URL path: http://www.cng.fr/en/projects/fp6_star.html (2016-01-29)
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  • CNG - PROGRAMMES
    Japan Programme Franco croatian coop PHENOGENE ID DNA tracing Using electronic identification eid and molecular markers dna for improving the traceability and meat Coordinator Contact Person Carles SOLA Professor Fax 46 18 551124 Web site http www uab es tracing Project description Although traceability is a sensitive area for consumers very few methods for tracing meat have been developed so far With this aim a double system based on electronic identification EID and DNA profiling for tracing animals and meat should be developed according to EU regulations The knowledge of EID and related limiting factors in the use of bolus ruminants and injectable pig transponders should be improved The project will develop and test a competitive new reader and study the automatic recovery of transponders in the abattoir and data transfer animal to meat For DNA profiling the project will select genetic markers and compare sampling methods Finally the project will assess the implementation of a double system for the whole tracing and quality monitoring of beef and pork meats including the management of a database and a cost benefit analysis The project is linked with two other FAIR5th projects on food traceability and integrates into the previous and current research on livestock EID conducted by the EU it takes into account the current results of the IDEA project Primary objective developing a reliable system for livestock and meat traceability based on the joint use of electronic identification EID and molecular markers DNA The EID should provide a real time tagging and tracing back methodology for farm use and administrative purposes until slaughtering and DNA profiling should be the method used for checking the tracing back of animal identity carcasses and meat cuts in the whole meat industry Secondary objective developing and assessing a double system EID DNA for the

    Original URL path: http://www.cng.fr/en/projects/fp5_eiddna.html (2016-01-29)
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  • CNG - PROGRAMMES
    GENESKIN IMAGEN MOLPAGE MOLTOOLS PROCARDIS STAR European Programmes EU FP5 EID DNA tracing EPIGENOME EUMORPHIA EURAGEDIC EURNETGEN EUROAS GENOMIC BANK INFRAQTL MADO Other Programmes France Japan Programme Franco croatian coop PHENOGENE EPIGENOME Pilot Study for a Human Epigenome Project Coordinator Contact Person William Murray CAIRNS Mr Organisation GENOME RESEARCH LTD THE WELLCOME TRUST SANGER INSTITUTE The Wellcome Trust Genome Campus Hinxton CB10 1SA SAFFRON WALDEN UNITED KINGDOM Web site http www epigenome org Project description Objectives To demonstrate the feasibility of a full scale Epigenome Project in the future To compare the methylation pattern for a defined set of 150 genes encompassing two loci per gene of the Major Histocompatibility Complex for 40 selected tissues A very high throughput epigenotyping facility is being developed for the analysis of large numbers of samples and establish haplotypes for a medium size set Initial studies are performed on lymphocyte samples from affected families Only loci of variable methylation and generic influences of haplotype on epigenotype will therefore be discovered In the second phase keratinocyte biopsies will be obtained from strictly selected set of psoriasis patients and a number of unaffected controls Loci that have been shown to be subject to variable methylation will

    Original URL path: http://www.cng.fr/en/projects/fp5_epigenome.html (2016-01-29)
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  • CNG - PROGRAMMES
    EU FP5 EID DNA tracing EPIGENOME EUMORPHIA EURAGEDIC EURNETGEN EUROAS GENOMIC BANK INFRAQTL MADO Other Programmes France Japan Programme Franco croatian coop PHENOGENE EUMORPHIA Understanding human molecular physiology and pathology through integrated functional genomics in the mouse model Coordinator Contact Person Nigel WATTS Mr Organisation MEDICAL RESEARCH COUNCIL MAMMALIAN GENETICS UNIT Harwell OX11 0RD DIDCOT HARWELL CHILTON UNITED KINGDOM Project description The consortium will undertake an integrated approach to the development and characterisation of new mouse models of human diseases and in so doing contribute in a profound way to understanding human physiology and pathology The three main elements Phenotyping Mutagenesis and Informatics in the workplan run in parallel Each workpackage contains the following common themes Working groups to evaluate and integrate proposed assays to propose define standard protocols and consider animal welfare issues to disseminate the standard protocols to use the standard protocols to acquire baseline longitudinal data on a variety of inbred strains and relevant existing models to develop innovative phenotyping approaches for subsequent implementation Participants THE NETHERLANDS CANCER INSTITUTE ANTONI VAN LEEUWENHOEK HOSPITAL NETHERLANDS GSF RESEARCH CENTER FOR ENVIRONMENT AND HEALTH GERMANY UNIVERSITY OF LAUSANE SWITZERLAND GENOME RESEARCH LTD UNITED KINGDOM KAROLINSKA INSTITUTE SWEDEN UNIVERSITY OF MANCHESTER

    Original URL path: http://www.cng.fr/en/projects/fp5_eumorphia.html (2016-01-29)
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  • CNG - PROGRAMMES
    EUROHEAR FGENTCARD GABRIEL GENESKIN IMAGEN MOLPAGE MOLTOOLS PROCARDIS STAR European Programmes EU FP5 EID DNA tracing EPIGENOME EUMORPHIA EURAGEDIC EURNETGEN EUROAS GENOMIC BANK INFRAQTL MADO Other Programmes France Japan Programme Franco croatian coop PHENOGENE EURAGEDIC EUropean Rational Approach for the GEnetics of DIabetic Complications Coordinator Contact Person Christian BRECHOT Mr Organisation INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FACULTE DE MEDECINE PITIE SALPETRIERE U525 Boulevard de l Hôpital 91 75634 PARIS FRANCE Project description To develop an existing interdisciplinary research collaboration with the major objective of combining clinical and genetic approaches to identify the biological pathways involved in the pathogenesis of diabetic complications in human and rodents New genomic approaches will be applied to a unique set of clinical resources to create a study with high power to identify genetic variants This relies on the possibility for extensive analysis of single nucleotide polymorphisms SNPs and other variants of many candidate genes that can be identified from the human genome sequence and the availability in our laboratories of reliable high throughput technologies for large scale characterization of these genetic variants Part 1 Phenotypic characterization of individuals Part 2 Identification of genes and pathways implicated in the diabetic complications

    Original URL path: http://www.cng.fr/en/projects/fp5_euragedic.html (2016-01-29)
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  • CNG - PROGRAMMES
    EVA GEN2PHEN GEUVADIS LUPA READNA SYBARIS PROGRAMMES ARCHIVE European Programmes EU FP6 EURATOOLS EUROHEAR FGENTCARD GABRIEL GENESKIN IMAGEN MOLPAGE MOLTOOLS PROCARDIS STAR European Programmes EU FP5 EID DNA tracing EPIGENOME EUMORPHIA EURAGEDIC EURNETGEN EUROAS GENOMIC BANK INFRAQTL MADO Other Programmes France Japan Programme Franco croatian coop PHENOGENE EURNETGEN European network to develop genetic markers for essential hypertension Coordinator Contact Person Susan FERGUSON Mrs Tel 44 14 13304992 Fax 44 14 13302747 Email Contact Organisation UNIVERSITY OF GLASGOW DEPARTMENT OF MEDICINE AND THERAPEUTICS University Avenue G12 8QQ Glasgow UNITED KINGDOM Project description To develop and evaluate a panel of novel SNPs within 100 candidate genes characterised by a putative pathophysiological link to essential hypertension and or its complication These genetic markers will undergo initial evaluation including the construction of haplotypes and testing for their functional significance on the existing DNA banks DZ twins and parents and nuclear families recruited by EPOGH European Project On Genes in Hypertension study At the same time TDT family trios 600 are collected in Glasgow Paris and Milan A special emphasis is on uniform high fidelity phenotyping which is made possible by common standard operating procedures stringent quality control system and common protocols for data analysis

    Original URL path: http://www.cng.fr/en/projects/fp5_eurnetgen.html (2016-01-29)
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  • CNG - PROGRAMMES
    GENESKIN IMAGEN MOLPAGE MOLTOOLS PROCARDIS STAR European Programmes EU FP5 EID DNA tracing EPIGENOME EUMORPHIA EURAGEDIC EURNETGEN EUROAS GENOMIC BANK INFRAQTL MADO Other Programmes France Japan Programme Franco croatian coop PHENOGENE EUROAS GENOMIC BANK EUROAS European genomic bank and clinical genetic and immunogenetic database of Ankylosing Spondylitis and the other Spondyarthropathies Coordinator Contact Person Rose Marie VAN LERBERGHE Organisation ASSISTANCE PUBLIQUE HOPITAUX DE PARIS SERVICE DE RHUMATOLOGIE A Rue du Fbg St Jacques 27 Hopital Cochin 75674 PARIS FRANCE Project description Objectives To optimise and reinforce existing infrastructure of 6 partner laboratories and 9 clinical centres doing a task force To harmonise techniques already used DNA cell and sera extraction cell line establishment and to develop new techniques and standards To ensure quality control of HLA molecular typing procedures B27 subtyping distribution of reference DNA To provide a repository of Ankylosing Spondylitis AS and other Spondyarthropathies SPA DNA cells and sera thanks to up to 4000 already identified affected families with accurate clinical status affected unaffected disease severity allowing to determine susceptibility and severity factors of AS and SPA To coordinate fine gene mapping studies to identify new susceptibility MHC and non MHC genes To supply a centralised database with

    Original URL path: http://www.cng.fr/en/projects/fp5_euroas.html (2016-01-29)
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