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  • CNG - PROGRAMMES
    READNA SYBARIS PROGRAMMES ARCHIVE European Programmes EU FP6 EURATOOLS EUROHEAR FGENTCARD GABRIEL GENESKIN IMAGEN MOLPAGE MOLTOOLS PROCARDIS STAR European Programmes EU FP5 EID DNA tracing EPIGENOME EUMORPHIA EURAGEDIC EURNETGEN EUROAS GENOMIC BANK INFRAQTL MADO Other Programmes France Japan Programme Franco croatian coop PHENOGENE INFRAQTL Rodent models for oligogenic human diseases infrastructure facilitating the progression from genetics to the gene containing the putative aetiological variant to the functional validation of genes pathways Coordinator Organisation MEDICAL RESEARCH COUNCIL MAMMALIAN GENETICS UNIT Harwell OX11 0RD DIDCOT HARWELL CHILTON UNITED KINGDOM Project description Genetic studies in rat and mouse models of human disorders have highlighted the complementary inputs provided by the two species in the genetic dissection of complex traits In order to take advantage of the access to novel gene functions promised by mouse and rat QTL studies an innovative infrastructure of both techniques and materials that provide strategic support for QTL research in Europe is prepared One of the major objectives is to co ordinate efforts and expertise between mouse and rat geneticists and to develop new infrastructures for QTL mapping high throughput genotype analysis and expression profiling systems applied to disease gene identification in rodents This project will lead to the

    Original URL path: http://www.cng.fr/en/projects/fp5_infraqtl.html (2016-01-29)
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  • CNG - PROGRAMMES
    registries socio economic evaluation of molecular techniques and recruitment strategies Coordinator Contact Person Christian BRECHOT Mr Organisation INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE U 558 EPIDMIOLOGIE ET ANALYSES EN SANT PUBLIQUE RISQUES MALADIES CHRONIQUES ET HANDICAPS AllTes Jules Guesde 37 FacultT de MTdTcine Purpan 37073 Toulouse FRANCE Project description Although 6 million potential donors are registered worldwide finding a donor compatible for allogenic stem cell graft is hard because of HLA polymorphism MADO aims at evaluating optimisation of Registries in Europe by increasing the proportion of donors presenting rare HLA combinations to reduce inequality of patients in a cost effective way The main concept is an evolving filter to screen potential donors at low cost before full HLA typing for the likely presence of frequent types The overall expected achievement is a number of well documented possible scenarios to help decision for organisation of coherent strategies of Registry management 1st axis Test and evaluation of a possible filter that would allow to screen potential donors at low cost before full HLA typing for the likely presence of frequent or rare combinations using new markers and new technological approaches that would be adaptable to the actual contents

    Original URL path: http://www.cng.fr/en/projects/fp5_mado.html (2016-01-29)
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  • CNG - PROGRAMMES
    Centre National de Génotypage Evry France CNG Human Genome Centre of the University of Tokyo Japan HGCT Summary The reference sequence of the human genome will be established by the Human Genome International Program in less than two years allowing the identification of all genes present in the genome For each individual many differences exist between his own sequence and the reference sequence in average one base every 1000 bases but ethnic origin and location of the studied genomic region modify the frequency of these differences The collaborative France Japan program aims to establish a genetic variant map a third generation map and to study their implication in inter individual differences for disease susceptibility or for specific phenotypic traits At the international level genetic variants discovery and their association to diseases represent the major research programs in post genomic era Objectives 1 To identify genetic variants in 15 000 genes in the following populations japanese european african Method After direct sequencing of DNA fragments amplified from 32 individuals for each population genetic variants are identified by comparison of sequence Oligonucleotides primers designed for the screening of genetic variants cover exons part of introns and promotors of the 15000 studied genes 2 To develop SNP genotyping technologies Both centers develop high throughput genotyping platforms with the objective to increase throughput and to lower production cost A MALDI TOF mass spectrometry genotyping platform has been set up at the CNG The HGCT and the CNG study alternative technological approaches with external partners 3 To study associations between genetic variants and diseases The CNG and the HGCT have collaborations with many groups to establish large patients cohorts to study common pathologies such as asthma diabetic complications and myocardial infarction Association studies will therefore be performed in two or more populations 4 To design

    Original URL path: http://www.cng.fr/en/projects/other_fr_jap.html (2016-01-29)
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  • CNG - PROGRAMMES
    SYBARIS PROGRAMMES ARCHIVE European Programmes EU FP6 EURATOOLS EUROHEAR FGENTCARD GABRIEL GENESKIN IMAGEN MOLPAGE MOLTOOLS PROCARDIS STAR European Programmes EU FP5 EID DNA tracing EPIGENOME EUMORPHIA EURAGEDIC EURNETGEN EUROAS GENOMIC BANK INFRAQTL MADO Other Programmes France Japan Programme Franco croatian coop PHENOGENE Franco croatian cooperation The role of bioinformatics in SNP detection in the human genome Coordinator Contact Person MARGETIC Nino Centre National de Génotypage France Partner s GLAVAS OBROVAC Ljubica Strossmayer University Osijek Croatia Summary Les causes génétiques des maladies auto immunes sont à l heure actuelle un de axes de recherche prioritaires du CNG et l objectif de ce programme est d établir une collaboration scientifique spécifique afin d avoir la possibilité d accéder au matériel biologique Les partenaires croates recherchent l association de polymorphismes du gène du récepteur de la vitamine D VDR avec la prédisposition au développement de la maladie dans des familles ayant un caractère d hérédité aux maladies thyroïdiennes auto immunes maladie de Basedow et maladie d Hashimoto En étroite collaboration avec un établissement hospitalier centre local dédié aux maladies thyroïdiennes ils possèdent de vastes compétences cliniques dans le diagnostic et le traitement des maladies auto immunes et bénéficient d un accès direct aux

    Original URL path: http://www.cng.fr/en/projects/other_fr_cro.html (2016-01-29)
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  • CNG - PROGRAMMES
    STAR European Programmes EU FP5 EID DNA tracing EPIGENOME EUMORPHIA EURAGEDIC EURNETGEN EUROAS GENOMIC BANK INFRAQTL MADO Other Programmes France Japan Programme Franco croatian coop PHENOGENE PHENOGENE PHENOGENE a Biological Resource centre of genetic variants for the development of animal models of human pathologies Coordinator Contact Person LATHROP Mark Centre National de Génotypage France Partner s PUECH Anne Centre National de Génotypage France Summary The aim of PHENOGENE program is

    Original URL path: http://www.cng.fr/en/projects/other_phenogene.html (2016-01-29)
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  • CNG - Communiqué de presse
    EURATools co author five scientific articles and a community perspective signed by more than 250 rat researchers across the globe All six articles are published in the current rat research focus issue of the high impact factor journal Nature Genetics May 2008 EURATools is a highly integrated research project involving scientists from 17 research institutes in Europe and China Within the first two years of the project runtime it was established as voice of the European rat research community and contributed to international efforts to improve the knowledge about the rat genome and how the strong similarities between the rat and human genomes can advance understanding of human diseases by determination and mapping of single nucleotide variations The STAR Consortium and by investigation of the impact of copy number variations Guryev et al The rat is used as model organism to learn about common human diseases Several single genes were identified to play a role in cardiovascular and inflammatory diseases Jund is associated with glomerulonephritis a major cause of human kidney failure Behmoaras et al Osteoglycin Ogn is a determinant of left ventricular mass Petretto Sarwar et al and soluble epoxide hydrolase Ephx2 is a susceptibility gene for heart failure Monti Fischer et al Tim Aitman MRC Clinical Science Centre London and scientific coordinator of EURATools and Howard Jacob Medical College of Wisconsin and Principal Investigator of the Rat Genome Database RGD together with 28 further co authors brought together the Community Perspective Progress and prospects in rat genetics which shows the major achievements in using genetics and genomics research in the rat as a rout to a new understanding of a range of common human diseases The vision for the future outlines six fundamental principles for the continuation and strengthening of research in this model system EURATools co authored papers published in the May 2008 issue of Nature Genetics Aitman T Critser JK Dominiczak A Cuppen E Fernandez XM Flint J Gauguier D Geurts AM Gould M Harris PC Holmdahl R Hübner N Izsvak Z Jacob H Kuramoto T Kwitek AE Marrone A Mashimo T Moreno Quinn C Mullins J Mullins L Olsson T Riley L Saar K Serikawa T Shull JD Szpirer C Twigger SN Voigt B Worley K Progress and prospects in rat genetics a community perspective Behmoaras J Bhangal G Smith J McDonald K Mutch B Chin Lai P Domin J Game L Salama A Foxwell BM Pusey CD Cook HT Aitman TJ JunD is a determinant of macrophage activation and glomerulonephritis susceptibility Guryev V Saar K Adamovic T Verheul M van Heesch S Cook S Pravenec M Aitman T Jacob H Shull JD Hubner N Cuppen E Selection Bias and Functional Impact of DNA Copy Number Variation in the Rat Monti J Fischer J Paskas S Heinig M Schulz H Gösele C Heuser A Fischer R Schmidt C Schirdewan A Gross V Hummel O Maatz H Patone G Saar K Vingron M Weldon SM Hammock BD Rohde K Dietz R Cook SA Schunck W H

    Original URL path: http://www.cng.fr/fr/news/pr_apr2008_en.html (2016-01-29)
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  • CNG - Communiqué de presse
    remarquables dans l identification des variations génétiques SNP du génome humain estimées comme pouvant être à la base de la prédisposition à de nombreuses maladies ou responsable de la réponse individuelle à des traitements médicaux La faisabilité de ces études est apparue en 2006 lorsque des outils puissants ont permis de détecter la distribution de centaine de milliers de SNP sur l ensemble du génome humain et de détecter les associations entre une variation ou des variations données et une maladie particulière Ceci est réalisé en comparant des milliers d échantillons provenant de personnes atteintes de cette maladie cas et de personnes non atteintes témoins A partir des études d association pan génomiques il est possible de déterminer le facteur de risque de la maladie associé à un SNP Avant 2007 nous n avions qu une connaissance limitée des variations génétiques impliquées dans la prédisposition aux maladies Des études pilotes à grande échelle initiées en 2006 ont donné des résultats probants en 2007 et de nombreuses variations génétiques prédisposant à des maladies telles que l infarctus du myocarde les cancers les diabètes de nombreuses maladies auto immunes et même des maladies infectieuses ont été identifiées Le Centre National de Génotypage CNG qui a été récemment intégré au CEA à travers la création de l Institut de Génomique joue un rôle de premier plan en France et au niveau international dans ce secteur Le CNG a publié des articles de référence en 2007 sur des maladies comme l asthme la maladie de Crohn maladie inflammatoire chronique de l intestin les maladies cardiovasculaire infectieuse et a identifié des gènes pouvant modifier la sévérité de certaines maladies De nombreuses autres avancées sont attendues en 2008 dans le cadre du programme national en génomique du cancer notamment pour le cancer du poumon du rein

    Original URL path: http://www.cng.fr/fr/news/pr_jan2008_fr.html (2016-01-29)
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  • CNG - Laboratoire Haut Débit
    and liver gene transcriptional changes underlie diet induced fatty liver susceptibility in insulin resistant mice Diabetologia 50 9 1867 1879 2007 DUMAS M E WILDER S P BIHOREAU MT BARTON R H FEARNSIDE J F ARGOUD K D AMATO L WALLIS R H BLANCHER C KEUN H C BAUNSGAARD D SCOTT J SIDELMANN U G NICHOLSON J K and GAUGUIER D Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models Nat Genet 39 5 666 672 2007 RAMAGOPALAN S V DELUCA G C MORRISON K M HERRERA B M DYMENT D A ORTON S BIHOREAU MT DEGENHARDT A PUGLIATTI M SADOVNICK A D SOTGIU S and EBERS G C No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosis J Neuroimmunol 186 1 2 156 160 2007 ARGOUD K WILDER S P McATEER M A BIHOREAU MT OUALI F WOON P Y WALLIS R H KTORZA A and GAUGUIER D Genetic control of plasma lipid levels in a cross derived from normoglycaemic Brown Norway and spontaneously diabetic Goto Kakizaki rats Diabetologia 49 11 2679 2688 2006 COLLINS S C WALLIS R H WILDER S P WALLACE K J ARGOUD K KAISAKI P J BIHOREAU MT and GAUGUIER D Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto Kakizaki rats Mamm Genome 17 6 538 547 2006 WOON P Y CURTIS A M KAISAKI P J ARGOUD K WALLACE K J BIHOREAU MT FITZGERALD G A and GAUGUIER D Genomic organization of the rat Clock gene and sequence analysis in inbred rat strains Genomics 87 2 208 217 2006 MASOUDI NEJAD A NASUDA S BIHOREAU MT WAUGH R and ENDO T R An alternative to radiation hybrid mapping for large scale genome analysis in barley Mol Genet Genomics 274 6 589 594 2005 BIHOREAU MT BROWN J H HOFFMANN S KRANZLIN B TYCHINSKAYA I OBERMULLER N PODLICH D BOEHN S N KAISAKI P J MEGEL N DANOY P COPLEY R R BROXHOLME J WITZGALL R LATHROP M GRETZ N and GAUGUIER D Missense mutation in sterile alpha motif of novel protein SamCystin is associated with polycystic kidney disease in cy rat J Am Soc Nephrol 16 12 3517 3526 2005 GAUGUIER D BEHMOARAS J ARGOUD K WILDER S P PRADINES C BIHOREAU MT OSBORNE PELLEGRIN M and JACOB MP Chromosomal mapping of quantitative trait loci controlling elastin content in rat aorta Hypertension 45 3 460 466 2005 WALLACE K J WALLIS R H COLLINS S C ARGOUD K KAISAKI P J KTORZA A WOON P Y BIHOREAU MT and GAUGUIER D Quantitative Trait Locus dissection in congenic strains of the Goto Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q Physiol Genomics 19 1 1 10 2004 GAUGUIER D VAN LUIJTELAAR G BIHOREAU MT WILDER S P GODFREY R VOSSEN J COENEN A and COX R D Chromosomal mapping of genetic loci controlling absence epilepsy phenotypes in the WAG Rij Rat Epilepsia 45 8 908 915 2004 WALLIS R H WALLACE K J COLLINS S C McATEER M ARGOUD K BIHOREAU MT KAISAKI P J and GAUGUIER D Enhanced insulin secretion and cholesterol metabolism in congenic strains of the spontaneously diabetic type 2 Goto Kakizaki rat are controlled by independent genetic loci in rat chromosome 8 Diabetologia 47 6 1096 106 2004 WILDER S P BIHOREAU MT ARGOUD K WATANABE T LATHROP M and GAUGUIER D Integration of the rat recombination and EST maps in the rat genomic sequence and comparative mapping analysis with the mouse genome Genome Res 14 4 758 765 2004 RUDOLF G BIHOREAU MT GODFREY R F WILDER S P COX R D LATHROP M MARESCAUX C and GAUGUIER D Polygenic Control of Idiopathic Generalized Epilepsy Phenotypes in the Genetic Absence Rats from Strasbourg GAERS Epilepsia 45 4 301 8 2004 COLLINS S C WALLIS R H WALLACE K BIHOREAU MT and GAUGUIER D Marker assisted congenic screening MACS a database tool for the efficient production and characterization of congenic lines Mamm Genome 14 5 350 356 2003 RAMANATHAN S BIHOREAU MT PATERSON A D MARANDI L GAUGUIER D and POUSSIER P Thymectomy and radiation induced type 1 diabetes in nonlymphopenic BB rats Diabetes 51 2975 2981 2002 BIHOREAU MT MEGEL N BROWN J H KRANZLIN B CROMBEZ L TYCHINSKAYA Y BROXHOLME J KRATZ S BERGMANN V HOFFMAN S GAUGUIER D and GRETZ N Characterization of a major modifier locus for polycystic kidney disease Modpkdr1 in the Han SPRD cy rat in a region conserved with a mouse modifier locus for Alport syndrome Hum Mol Genet 11 2165 73 2002 FRANTZ S CLEMITSON J BIHOREAU MT GAUGUIER D and SAMANI N J Genetic dissection of region around the Sa gene on rat chromosome 1 Evidence for multiple loci affecting blood pressure Hypertension 38 216 221 2001 BIHOREAU MT SEBAG MONTEFIORE L GODFREY R F WALLIS R H BROWN J H DANOY P A COLLINS S C ROUARD M KAISAKI P J LATHROP M and GAUGUIER D A high resolution consensus linkage map of the rat integrating radiation hybrid and genetic maps Genomics 75 57 69 2001 NANDROT E DUFOUR E M PROVOST A C PEQUIGNOT M O BONNEL S GOGAT K MARCHANT D ROUILLAC C SEPULCHRE D E CONDE B BIHOREAU MT SHAVER C DUFIER J L MARSAC C LATHROP M MENASCHE M and ABITBOL M M Homozygous deletion in the coding sequence of the c mer gene in RCS rats unravels general mechanisms of physiological cell adhesion and apoptosis Neurobiol Dis 7 6 Pt B 586 599 2000 ZAGATO L TRIPODI G BIHOREAU MT CASARI G MODICA R TORIELLI L BARBER B LATHROP G M and BIANCI G Genetic dissection of blood pressure in the MHS rat Hypertension 36 5 734 739 2000 GÖSELE C HONG L KREITLER T ROSSMANN M HIEKE B GROS U KRAMER M HIMMELBAUER H BIHOREAU MT KWITEK BLACK A E TWIGGER S TONELLATO P J JACOB H J SCHALKWYK L

    Original URL path: http://www.cng.fr/fr/organisation/laboratories/haut_debit/bihoreau_publ.html (2016-01-29)
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