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  • CNG - Programmes
    and immunology into the causes of asthma in the European Community Exceptional epidemiological and clinical surveys have already been assembled of childhood and adult asthma with inclusive information on environmental factors such as tobacco smoke air pollution nutrition allergen exposure and industrial agents DNA and serum have been stored for analyses This resource of 40 000 subjects will be extended to include severe asthmatics for genomic and proteomic analyses GABRIEL will comprehensively screen candidate genes and perform whole genome association studies to identify all important genetic influences on asthma with unmatched power to verify positive findings The large body of results from the study will be exploited by statistical and bioinformatics groups experienced in handling data of this complexity GABRIEL will identify all important gene environment interactions underlying asthma in the European Community and the results will be translated in cellular and genomic models to identify their molecular mechanisms Microbial exposures in rural farming environments result in a dramatic reduction in the development of asthma indicating that effective tools for the prevention of asthma can be developed The consortium will therefore systematically study rural farming environments Cellular and genomic models to identify the molecular mechanisms of protective environments will be developed as screens for novel therapeutics and the commercialisation of consortium results GABRIEL contains a strong and innovative ethical component which together with involvement of the JRC will ensure integration of the results into the European knowledge base for patient understanding and disease prevention Participants BCF DIAGNOSTICS LTD IRELAND COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FRANCE CORPORACION DE PROMOCION UNIVERSITARIA UNIVERSIDAD SAN FRANCISCO DE QUITO ECUADOR INSTITUTE OF MEDICAL GENETICS TOMSK SCIENTIFIC CENTER OF THE SIBERIAN BRANCH OF RUSSIAN ACADEMY OF MEDICAL SCIENCES RUSSIAN FEDERATION INSTITUTE OF BIOCHEMISTRY AND GENETICS OF UFA SCIENCE CENTRE OF RAS RUSSIAN

    Original URL path: http://www.cng.fr/fr/projects/fp6_gabriel.html (2016-01-29)
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  • CNG - Programmes
    LABORATORY OF CANCER GENETICS LABORATORY OF MOLECULAR AND CELL BIOLOGY Via dei Monti di Creta 104 ITALY Project description Genetic skin diseases comprise almost 300 rare but often severe and even life threatening diseases and syndromes Despite recent identification of causative genes in a number of these disorders the molecular bases of several others are still unknown and often the function of the identified disease gene products remains an unsolved mystery In addition disease number and rarity impair proper management and no curative therapy is available By bringing together clinicians researchers and patient associa tions GENESKIN aims to generate accessible knowledge and improve health care service structures for affected people The focus is on five major disease categories epithelial adhesion disorders keratinization disorders ectodermal dysplasias connective tissue diseases DNA repair disorders For each group a clinical and laboratory network will generate and disseminate a list of reference centers with services offered diagnostic questionnaires protocols gene cards mutation database diagnost ic reagent lists and ongoing clinical trial list The research topics to be co ordinated in GENESKIN deal with improved early post natal and pre natal diagnosis by novel immunohistochemical biochemical and molecular tests identification of new genes involved in genetic skin diseases by collecting a sizable number of biological samples definition of genotype phenotype correlation and characterisation of newly identified gene product functions by creation of a sample Databank Knowledge dis semination and improved management will also be insured through the organisation of involved personnel training Finally pan European communication among patients organisations ethic committees physicians and scientist will be promoted The informati on regarding clinical diagnostic protocols lists diagnostic and research tools and communication among different groups will be integrated and disseminated through a dedicated web site Participants INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE FRANCE

    Original URL path: http://www.cng.fr/fr/projects/fp6_geneskin.html (2016-01-29)
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  • CNG - Programmes
    Contact Organisation KING S COLLEGE LONDON SGDP CENTRE Strand LONDON UNITED KINGDOM Project description A fundamental function of the brain is to evaluate motivational and emotional significance of stimuli and to adapt behaviour accordingly We hypothesize that genetically influenced individual differences in brain responses to reward punishment and emotional cues in adolescents mediate risk for mental disorders with a major public health impact Neuroimaging permits the measurement of specific brain functions implicated in the etiology of mental disorders and link them to genetic variations and behavioural characteristics relevant to disease processes The goal of the present study is to identify the neurobiological and genetic bases of these traits and to assess their relevance for mental disorder To this end we will perform the first multicentre functional and structural genetic neuroimaging study of a cohort of 2000 14 year old adolescents Intermediate phenotypes of risk for adolescent mental illness will be explored based on cognitive behavioural clinical and neuroimaging data To determine the predictive value of intermediate phenotypes and genetics for development of mental disorders our cohort will be psychometrically assessed during recruitment and longitudinally at year 4 age 16 18 of this proposal DNA samples and phenotype database for the cohort will create a powerful resource for present and future genetic investigations In the present study we will assess association with markers of genes chosen from existing genomic information and from our studies of animals selected for extreme phenotypes of impulsivity and other relevant behavioural traits Results obtained will be validated in 1000 siblings from the Canadian Saguenay youth neuroimaging study The IMAGEN study will help elucidate the neural basis of mental disorders and will lay the groundwork for development of treatments that target specific pathological processes across mental disorders rather than heterogeneous categories of mental illness Participants TECHNISCHE UNIVERSTITÄT

    Original URL path: http://www.cng.fr/fr/projects/fp6_imagen.html (2016-01-29)
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  • CNG - Programmes
    BELL John Professor Tel 44 1865221340 Email Contact Organisation THE CHANCELLORS MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD OXFORD CENTRE FOR DIABETES ENDOCRINOLOGY AND METABOLISM OCDEM NUFFIELD DEPARTMENT OF CLINICAL MEDICINE University Offices Wellington Square UNITED KINGDOM Project description Epidemiologists clinical trialists and experimental scientists are confronted with a wealth of potential opportunities for molecular phenotyping large numbers of biological samples obtained from cohorts patients or animal models The challenge now is to ensure that these tools are developed to permit high throughput analyses of significant numbers of samples cohort protocols are in place for sample collection and storage and that systems are in place to capture warehouse and analyse the range of biolog ical data that will emerge from these studies This consortium will bring some of these tools into practice during the course of the next four years so that they can be used to identify biomarkers that predict disease determine risk and relate to disease activity or response to therapy The programme is divided into three parts The evaluation of sample collection and storage methodology to optimally sample variation and disease analyte stability The development of tools for molecular phenotyping at epidemiologic scale including measuring small molecules metabonomics mRNA in white blood cells transcription profiling protein and peptide analysis using mass spectrometry methodology affinity arrays and tissue arrays DNA methdylation patterns and genetics The development of bioinformatic tools for data warehousing data interrogation and statistical analysis in large sample sets The consortium will adopt two separate approaches genome wide systematic methodology metabonomics ms based metanomics and limited analysis using sets of candidate biomarkers transcipt profiling methylation affinity arrays tissue arrays Collectively these programmes bring together the necessary skills and tools to allow moleculear phenotyping to be realistically applied informing our study of common disease and its

    Original URL path: http://www.cng.fr/fr/projects/fp6_molpage.html (2016-01-29)
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  • CNG - Programmes
    croate PHENOGENE MOLTOOLS Advanced molecular tools for array based analyses of genomes transcriptomes proteomes and cells Coordinator Contact Person LANDEGREN Ulf Professor Tel 46 184714910 Fax 46 184714808 Email Contact Organisation UPPSALA UNIVERSITET DEPARTMENT OF GENETICS AND PATHOLOGY St Olofsgatan 10B PO Box 256 SWEDEN Project description The recording of complete genome sequences provides for the first time opportunities to comprehensively characterize the flow of information from genetic variation at the DNA level over messages expressed as RNA and on to their protein products and to functions of the cell By eavesdropping on these processes it will be possible to identify genetic variation underlying malignancy diabetes and other common diseases and to monitor and ultimately explain molecular processes involved in these and other important conditions Recent years have seen rapid growth of techniques for high throughput analyses of genes transcripts proteins and cells using microarrays but current methods still capture only a small fraction of the information embodied in the molecules This project brings together leading European laboratories and one US lab The purpose is to build an infrastructure to develop a next generation toolbox for large scale molecular analyses in the following six interrelated analytical modes parts of whole genomes will be rapidly scanned for any alterations extensive sets of genetic variants will be traced in large numbers of individuals patterns of gene expression will be recorded at unprecedented quantitative and sequence resolution expression and interactions of large sets of proteins will be measured in array formats novel molecular tools will enable analyses at the ultimate level of single DNA RNA or protein molecules and arrays of viable cells will permit extensive functional analyses to characterise complex processes in high throughput The suite of microarray based technologies developed in the course of this program will be of strategic value

    Original URL path: http://www.cng.fr/fr/projects/fp6_moltools.html (2016-01-29)
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  • CNG - Programmes
    franco japonaise franco croate PHENOGENE PROCARDIS A genome wide mapping and functional genomics approach to elucidating precocious coronary artery disease Coordinator Contact Person WATKINS Hugh Professor Tel 44 1865220257 Fax 44 1865768844 Email Contact Organisation THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD CLINCAL TRIALS SERVICE UNIT AND THE DEPARTMENT OF PUBLIC HEALTH AND PRIMARY CARE DEPARTMENT OF CARDIOVASCULAR MEDICINE University Offices Wellington Square UNITED KINGDOM Project description Procardis is a European Commission Framework 6 FP6 funded project which exploits advances in complex trait genetics and functional genomics to discover novel susceptibility genes for coronary artery disease CAD PROCARDIS is incorporating a definitive genome wide association analysis and measurement of novel intermediate phenotypes to yield biomarkers for CAD risk and quantitative traits for genetic analysis Cardiovascular mortality and morbidity in Europe which represents 1 3 to 1 2 of overall mortality rates hardly needs to be underlined Two well recognised general features characterise the cardiovascular mortality figures within Europe of which CAD accounts for between 1 3 and 2 3 a great inter country variability with decreasing East West and North South gradients and a falling prevalence in the Western and Southern countries contrasting the stable increasing rates in many Eastern countries The need for targeted studies with the aim of exploring the specific interaction between genetic and environmental risk factors is recognised as a priority The specific aims of the Procardis project are identify novel proteins and pathways implicated in atherosclerosis and arterial thrombosis define new targets for prevention and treatment devise diagnostic tools The Procardis project is funded with 10 million Euros through the 6th Framework Program of the European Union LSH 2005 2 1 1 1 The project is aimed to integrate the efforts of key European basic and clinical scientists into one cohesive effort

    Original URL path: http://www.cng.fr/fr/projects/fp6_procardis.html (2016-01-29)
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  • CNG - Programmes
    description Inherited differences in DNA sequence contribute to phenotypic variation influencing an individual s risk of disease and response to the environment A central goal of genetics is to pinpoint the DNA variants that contribute most significantly to variation in each trait The rat is an important model organism for systems biology provides the most relevant models of common multifactorial human disease and it is by far the leading model species in pharmacology and toxicology It has been the major model for physiological investigation providing a body of data on patho physiology including detailed mechanistic biochemical and metabolic characterisation that cannot be replaced by other models Decades of exquisite phenotyping and detailed analysis of crosses of inbred rats have resulted in initial localization of hundreds of loci involved in complex disease and quantitative phenotypes but with very few eventual gene identifications to date A clear understanding of the origin and structure of genetic variation in the rat will provide a key missing piece of this puzzle To fully realize the power of the recent rat genome sequence we propose to initiate the complete genetic dissection of the ancestral segments making up the most commonly used inbred lines The proposed SNP

    Original URL path: http://www.cng.fr/fr/projects/fp6_star.html (2016-01-29)
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  • CNG - Programmes
    programmes franco japonaise franco croate PHENOGENE ID DNA tracing Using electronic identification eid and molecular markers dna for improving the traceability and meat Coordinator Contact Person Carles SOLA Professor Fax 46 18 551124 Web site http www uab es tracing Project description Although traceability is a sensitive area for consumers very few methods for tracing meat have been developed so far With this aim a double system based on electronic identification EID and DNA profiling for tracing animals and meat should be developed according to EU regulations The knowledge of EID and related limiting factors in the use of bolus ruminants and injectable pig transponders should be improved The project will develop and test a competitive new reader and study the automatic recovery of transponders in the abattoir and data transfer animal to meat For DNA profiling the project will select genetic markers and compare sampling methods Finally the project will assess the implementation of a double system for the whole tracing and quality monitoring of beef and pork meats including the management of a database and a cost benefit analysis The project is linked with two other FAIR5th projects on food traceability and integrates into the previous and current research on livestock EID conducted by the EU it takes into account the current results of the IDEA project Primary objective developing a reliable system for livestock and meat traceability based on the joint use of electronic identification EID and molecular markers DNA The EID should provide a real time tagging and tracing back methodology for farm use and administrative purposes until slaughtering and DNA profiling should be the method used for checking the tracing back of animal identity carcasses and meat cuts in the whole meat industry Secondary objective developing and assessing a double system EID DNA for the

    Original URL path: http://www.cng.fr/fr/projects/fp5_eiddna.html (2016-01-29)
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